教職

國防醫學院病理學科教授

經歷

1. 三軍總醫院病理部電鏡診斷室主任
2. 三軍總醫院病理部外科病理科主任
3. 三軍總醫院病理部部主任
4. 國防醫學院病理暨寄生蟲學研究所所長
5. 國軍法醫中心副主任|
6. 三軍總醫院人體生物資料庫生物醫學主管
7. 預防醫學研究所所長

專長學科

1. 乳癌的流行病學及分子病理學研究
2. 腎細胞癌的流行病學及分子病理學研究
3. 肺癌的分子病理學研究

E-mail

[email protected]

Selected Publications

1. Lai HC, Sytwu HK, Sun CA, Yu MH, Yu CP, Liu HS, Chang CC, Chu TY. Single nucleotide polymorphism at Fas promoter is associated with cervical carcinogenesis. Int J Cancer. 2003;103(2):221-5.



2. Cheng YL, Lee SC, Harn HJ, Chen CJ, Chang YC, Chen JC, Yu CP. Prognostic prediction of the immunohistochemical expression of p53 and p16 in resected non-small cell lung cancer. Eur J Cardiothorac Surg. 2003;23(2):221-8.



3. Liu YC. Kuo YL. Yu CP. Wu HS. Yu JC. Chen CJ. Chan DC. Yu CY. Hsieh CB. Chen TW. Primary malignant mesothelioma of the greater omentum: report of a case. Surgery Today. 2004; 34(9):780-3.



4. Huang RL. Chao CF. Ding DC. Yu CP. Chang CC. Lai HC. Yu MH. Liu HS. Chu TY. Multiple epithelial and nonepithelial tumors in hereditary nonpolyposis colorectal cancer: characterization of germline and somatic mutations of the MSH2 gene and heterogeneity of replication error phenotypes. Cancer Genetics & Cytogenetics. 2004; 153(2):108-14.



5. Lin WY. Chou YC. Wu MH. Huang HB. Jeng YL. Wu CC. Yu CP. Yu JC. You SL. Chu TY. Chen CJ. Sun CA. The MTHFR C677T polymorphism, estrogen exposure and breast cancer risk: a nested case-control study in Taiwan. Anticancer Research. 2004; 24(6):3863-8.



6. Chen DC. Chen CH. Su HY. Yu CP. Chu TY. Huge pedunculated fibroma of the vulva. Acta Obstetricia et Gynecologica Scandinavica. 2004; 83(11):1091-2.



7. Lee SC. Tzao C. Ou SM. Hsu HH. Yu CP. Cheng YL. Solitary fibrous tumors of the pleura: clinical, radiological, surgical and pathological evaluation. European Journal of Surgical Oncology. 2005;31: 84-87.



8. Lin SC. Chou YC. Wu MH. Wu CC. Lin WY. Yu CP. Yu JC. You SL. Chen CJ. Sun CA. Genetic variants of myeloperoxidase and catechol-O-methyltransferase and breast cancer risk. European Journal of Cancer Prevention. 2005;14: 257-261.



9. Chang WC. Tzao C. Shen DH. Cheng CY. Yu CP. Hsu HH. Gastrointestinal stromal tumor (GIST) of the esophagus detected by positron emission tomography/computed tomography. Digestive Diseases & Sciences. 2005;50: 1315-1318.



10. Chen DC. Chen CH. Su HY. Yu CP. Yu MH. Retroperitoneal lymphangiomyomas presenting as a pelvic mass. Acta Obstetricia et Gynecologica Scandinavica. 2005;84: 917-920.



11. Liu YC. Shen CY. Wu HS. Chan DC. Chen C J. Yu JC. Yu CP. Harn HJ. Shyu RY. Shih Y L. Hsieh CB. Hsu HM. Helicobacter pylori infection in relation to E-cadherin gene promoter polymorphism and hypermethylation in sporadic gastric carcinomas. World Journal of Gastroenterology. 2005;11: 5174-5179.



12. Tzao C. Hsu HS. Sun GH. Lai HL. Wang YC. Tung HJ. Yu CP. Cheng YL. Lee SC. Promoter methylation of the hMLH1 gene and protein expression of human mutL homolog 1 and human mutS homolog 2 in resected esophageal squamous cell carcinoma. Journal of Thoracic & Cardiovascular Surgery. 2005; 130: 1371.



13. Lee TP. Tzao C. Liu JH. Yu CP. Hsu HH. Chien HN. Isolated endobronchial metastasis of Wilms' tumor. Journal of Pediatric Surgery. 2005; 40: e33-e35.



14. Wu MH. Chou YC. Yu JC. Yu CP. Wu CC. Chu CM. Yang T. Lai CH. Hsieh CY. You SL. Chen CJ. Sun CA. Hormonal and body-size factors in relation to breast cancer risk: a prospective study of 11,889 women in a low-incidence area. Annals of Epidemiology. 2006, 16: 223-229.



15. Liu YC. Shen CY. Wu HS. Hsieh TY. Chan DC. Chen CJ. Yu JC. Yu CP. Harn HJ. Chen PJ. Hsieh CB. Chen TW. Hsu HM. Mechanisms inactivating the gene for E-cadherin in sporadic gastric carcinomas. World Journal of Gastroenterology. 2006, 12: 2168-2173.



16. Lai HC. Peng MY. Nieh S. Yu CP. Chang CC. Lin YW. Sun CA. Chu TY. Differential viral loads of human papillomavirus 16 and 58 infections in the spectrum of cervical carcinogenesis. International Journal of Gynecological Cancer. 2006, 16: 730-735.



17. Chen CH. Chen SG. Wu GJ. Wang J. Yu CP. Liu JY. Autologous heterotopic transplantation of intact rabbit ovary after frozen banking at -196 degrees C. Fertility & Sterility. 2006, 86 Suppl 4:1059-1066.



18. Hsu GC. Ku CH. Yu JC. Hsieh CB. Yu CP. Chao TY. Application of intraoperative ultrasound to nonsentinel node assessment in primary breast cancer. Clinical Cancer Research. 2006, 12: 3746-3753.



19. Lee SS. Tang SH. Sun GH. Yu CP. Jin JS. Chang SY. Limited Wegener's granulomatosis of the epididymis and testis. Asian Journal of Andrology. 2006, 8: 737-739.



20. Kao HW. Yu CP. Tzao C. Lin WC. Hsu HH. Chen CY. An unusual case of thymic carcinoma with endobronchial metastases manifesting as centrilobular opacities. Journal of Thoracic Imaging. 2006, 21: 238-240.



21. Jin JS. Yu CP. Sun GH. Lin YF. Chiang H. Chao TK. Tsai WC. Sheu LF. Increasing expression of fascin in renal cell carcinoma associated with clinicopathological parameters of aggressiveness. Histology & Histopathology. 2006, 21: 1287-1293.



22. Chen DC. Hsu HH. Yu CP. Chen CH. Chu TY. Improvement in uterine choriocarcinoma complicated by life-threatening pulmonary infarction. Acta Obstetricia et Gynecologica Scandinavica. 2006, 85: 370-373.



23. Chen YF. Lee SP. Yu CP. Chiang CP. Ehlers-Danlos syndrome type III – A case report. Dermatologica Sinica. 2006, 24: 150-154.



24. Jin JS. Wu CY. Lin YF. Wang JY. Yu CP. Sheu LF. Chiang H. Tsai WC. Lee WH. Higher expression of epidermal growth factor receptor is associated with extracellular matrix metalloprotease inducer in colorectal adenocarcinoma: Tissue microarray analysis of immunostaining score with clinicopathological parameters. Disease Markers. 2006, 22: 309-316.



25. Yu JC. Hsu GC. Hsieh CB. Yu CP. Chao TY. Role of sentinel lymphadenectomy combined with intraoperative ultrasound in the assessment of locally advanced breast cancer after neoadjuvant chemotherapy. Annals of Surgical Oncology. 2007, 14: 174-180.



26. Jin JS. Cheng TF. Tsai WC. Sheu LF. Chiang H. Yu CP. Expression of the serine protease, matriptase, in breast ductal carcinoma of Chinese women: correlation with clinicopathological parameters. Histology & Histopathology. 2007, 22: 305-309.



27. Yu CP, Wu MH, Chou YC, Yang T, You SL, Chen CJ, Sun CA. Breast cancer risk associated wtih multigenotypic polymorphisms in folate-metabolizing genes: a nested case-control study in Taiwan. Anticancer Research 2007; 27: 1727-1732.



28. Chen CC. Ko TM. Ma HI. Wu HL. Xiao X. Li J. Chang CM. Wu PY. Chen CH. Han JM. Yu CP. Jeng KS. Hu CP. Tao MH. Long-term inhibition of hepatitis B virus in transgenic mice by double-stranded adeno-associated virus 8-delivered short hairpin RNA. Gene Therapy. 2007, 14: 11-19.



29. Yu CP, Yu JC, Sun CA, Tzao C, Ho JY, Yen AMF. Tumor susceptibility and prognosis of breast cancer associated with the G870A polymorphism of CCND1. Breast Cancer Res Tr. 2008, 107: 95-102.



30. Tzao C, Lee SC, Tung HJ, Hsu HS, Hsu WH, Sun GH, Yu CP, Jin JS, Cheng YL. Expression of hypoxia-inducible factor (HIF)-1alpha and vascular endothelial growth factor (VEGF)-D as outcome predictors in resected esophageal squamous cell carcinoma. Dis Markers. 2008; 25: 141-148.



31. Kao CC, Yu CP, Liu YC, Yu JC, Hsieh CB. Unusual presentation of cystic liver metastases from nasopharyngeal carcinoma. Onkologie. 2008; 31: 635-636.



32. Lee YY, Yu CP, Lin CK, Nieh S, Hsu KF, Chiang H, Jin JS. Expression of survivin and cortactin in colorectal adenocarcinoma: association with clinicopathological parameters. Dis Markers. 2009; 26: 9-18.



33. Tzao C, Tung HJ, Jin JS, Sun GH, Hsu HS, Chen BH, Yu CP, Lee SC. Prognostic significance of global histone modifications in resected squamous cell carcinoma of the esophagus. Mod Pathol. 2009; 22: 252-260.



34. Lin CK, Chao TK, Yu CP, Yu MH, Jin JS. The expression of six biomarkers in the four most common ovarian cancers: correlation with clinicopathological parameters. APMIS. 2009; 117: 162-175.



35. Huang WH, Wu CY, Yu CP, Chiang CP. Amyloidosis cutis dyschromica: four cases from two families. Int J Dermatol. 2009; 48: 518-521.



36. Lin WC, Hsu GC, Yu CP, Yu JC, Lee HN, Hsu HH, Chang TH, Chen T, Li CS, Huang GS. Value of sonographically guided needle sampling of cystic versus solid components in the diagnosis of complex cystic breast masses. Acta Radiol. 2009; 50: 595-601.



37. Juan TY, Roffler SR, Hou HS, Huang SM, Chen KC, Leu YL, Prijovich ZM, Yu CP, Wu CC, Sun GH, Cha TL. Antiangiogenesis targeting tumor microenvironment synergizes glucuronide prodrug antitumor activity. Clin Cancer Res. 2009; 15: 4600-4611.



38. Wang GC, Hsieh PS, Hsu HH, Sun GH, Nieh S, Yu CP, Jin JS. Expression of cortactin and survivin in renal cell carcinoma associated with tumor aggressiveness. World J Urol. 2009; 27: 557-563.



39. Hsu HH, Yu JC, Hsu GC, Chang WC, Yu CP, Tung HJ, Tzao C, Huang GS. Ultrasonographic alterations associated with the dilatation of mammary ducts: feature analysis and BI-RADS assessment. Eur Radiol. 2009 Aug 26 (in press).



40. Wu MH, Chou YC, Chou WY, Hsu GC, Chu CH, Yu CP, Yu JC, Sun CA. Relationships between critical period of estrogen exposure and circulating levels of insulin-like growth factor-I (IGF-I) in breast cancer: Evidence from a case-control study. Int J Cancer. 2010; 126: 508-514



41. Chen CK, Lee MY, Lin WL, Wang YT, Han CP, Yu CP, Chao WR. A Qualitative Study Comparing the Assay Performance Characteristics Between the 2007 and the 2013 American Society for Clinical Oncology and College of American Pathologists HER2 Scoring Methods in Mucinous Epithelial Ovarian Cancer. Medicine 2014 Dec, 93(27) : e171



42. Tsau HS, Yen MF, Fann CY, Wu YY, Cheng PY, Yu CP, Chen LS, Chiu YH, Laszlo Tabar, Kuo WH, Chen HH,Chang KJ.Mammographic tumor appearance and triple-negative breast cancer associated with long-term prognosis of breast cancer death: A Swedish Cohort Study. Cancer Epidemiol 2015 Apr; 39(2): 200-8



43. Lin SY, Yeh CT, Li WG, Yu CP, Lin WC, Yang JY, Wu HL, Hu YC. Enhanced enterovirus 71 virus-like particle yield from a new baculovirus design. Biotechnol Bioengeering 2015 May, 112(10)



44. Ho JY, Cheng FW, Huang FS, Liu JM. Liu YP, Chen SP, Liu YL, Cheng KC, Yu CP, Hsu RJ. Estrogen Enhances the Cell Viability and Motility of Breast Cancer Cells through the ERα-ΔNp63-Integrin β4 Signaling Pathway. PLoS One2016, 11(2)



45. Ho JY, Hsu RJ, Wu CH, Liao GS, Gao HW, Wang TH, Yu CP.Reduced miR-550a-3p leads to breast cancer initiation, growth, and metastasis by increasing levels of ERK1 and 2. Oncotarget 2016 Aug 16;7(33)



46. Ho JY, Hsu RJ, Liu JM, Chen SC, Liao GS, Gao HW, Yu CP MicroRNA-382-5p aggravates breast cancer progression by regulating the RERG/Ras/ERK signaling axis. Oncotarget 2017, Vol. 8,(No.14)



47. Lin SY, Sung LY, Yeh CT, Yu CP, Yang JY, Chen HY. Production and purification of virus-like particles of different enterovirus subtypes as vaccines. J Taiwan Inst Chem E.2018, 82(1-9)



48. Fann CY, Chang KJ, Hsu CY, Yen MF, Yu CP, Chen LS, WH Kuo, Laszlo Tabar, HH Chen, Impact of Overdiagnosis on Long-Term Breast Cancer Survival. Cancers 2019, 11(3),325