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頭頸癌分子生物實驗室
實驗介紹:本研究團隊是偵測癌幹細胞之特性暨開發新的癌症篩檢及治療方法,並研究癌幹細胞和其微環境特殊的互動關係。本研究小組主要利用細胞和分子病理學及轉殖基因的動物模型,研發調控癌細胞特異性蛋白及改變遺傳物質的產物,瞭解腫瘤的特質暨其應對之策略,達到癌症治療及預防之功效。
研究成員:饒樹文 教授、聶鑫 教授、林曜祥 副院長、陳素鳳 助理教授
博士生:張雲晶(國防生科所)、劉佳苓(國防生科所)、李才宇(陽明環職衛所)
碩士生:吳建樺(寄蟲所)、簡靖純(微免所)、洪千蘋(病理所)、曾嶧涵(病理所)
研究助理及臨床協同研究人員:黃文彥 醫師(放射腫瘤科)、張文玲 病理部細胞醫檢師
檔案下載:Lab Introduction(PDF)

  1. Cytoplasmic CD133 Expression is a Reliable Prognostic Indicator of Tumor Regression After Neoadjuvant Concurrent Chemoradiotherapy in Patients with Rectal Cancer. Jao SW, Chen SF, Lin YS *, Chang YC, Lee TY, Wu CC, Jin JS, Nieh S*. Ann Surg Oncol. DOI 10.1245/s10434-012-2394-3
  2. Nonadhesive culture system as a model of rapid sphere formation with cancer stem cell properties. Chen SF, Chang YC, Nieh S, Liu CL, Yang CY, Lin YS*. PLoS One. 2012;7(2):e31864. Epub 2012 Feb 16.
  3. The chemoadjuvant potential of grape seed procyanidins on p53-related cell death in oral cancer cells. Lin YS*, Chen SF, Liu CL, Nieh S *. J Oral Pathol Med. 2012 Apr;41(4):322-31.
  4. Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients. Jan CI, Yu CC, Hung MC, Harn HJ, Nieh S, Lee HS, Lou MA, Wu YC, Chen CY, Huang CY, Chen FN, Lo JF. J Pathol. 2011 Apr 18. doi: 10.1002/path.2921
  5. Role of human papillomavirus infection in carcinogenesis of oral squamous cell carcinoma with evidences of prognostic association. Chen SF, Yu FS, Chang YC, Fu E, Nieh S*, Lin YS. J Oral Pathol Med. 2011 May 20. doi: 10.1111/j.1600-0714.2011.01046.x.*Corresponding author
  6. Invasive pattern grading score designed as an independent prognostic indicator in oral squamous cell carcinoma. Chang YC, Nieh S, Chen SF, Jao SW, Lin YL, Fu E. Histopathology. 2010 Aug;57(2):295-303. Epub 2010 Jul 26. *Corresponding author
  7. Fascin, cortactin and survivin expression of melanocytic neoplasms and association with clinicopathological parameters and anatomic locations in Chinese people. Gao HW, Yu CP, Lee HS, Nieh S, Chiang CP, Wang WM, Jin JS. Eur J Dermatol. 2010 May-Jun;20(3):293-301. Epub 2010 Apr 16.
  8. Triptolide circumvents drug-resistant effect and enhances 5-fluorouracil antitumor effect on KB cells. Chen YW, Lin GJ, Chuang YP, Chia WT, Hueng DY, Lin CK, Nieh S, Sytwu HK. Anticancer Drugs. 2010 Jun;21(5):502-13.
  9. Treatment of a malignant peripheral nerve sheath tumor. Lin CT, Huang TW, Nieh S, Lee SC. Onkologie. 2009 Sep;32(8-9):503-5. Epub 2009 Jul 24.
  10. Effects of small interfering RNAs targeting Fascin on gene expression in oral cancer cells. Chen SF, Lin CY, Chang YC, Li JW, Fu E, Chang FN, Lin YL, Nieh S*. J Oral Pathol Med. 2009 Oct;38(9):722-30. Epub 2009 Apr 15. *Corresponding author
  11. Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human pancreas: implications for pathogenesis of alcohol-induced pancreatic injury. Chiang CP, Wu CW, Lee SP, Chung CC, Wang CW, Lee SL, Nieh S, Yin SJ. Alcohol Clin Exp Res. 2009 Jun;33(6):1059-68. Epub 2009 Mar 23.
  12. Expression of survivin and cortactin in colorectal adenocarcinoma: association with clinicopathological parameters. Lee YY, Yu CP, Lin CK, Nieh S, Hsu KF, Chiang H, Jin JS. Dis Markers. 2009;26(1):9-18.
  13. Expression of cortactin and survivin in renal cell carcinoma associated with tumor aggressiveness. Wang GC, Hsieh PS, Hsu HH, Sun GH, Nieh S, Yu CP, Jin JS. World J Urol. 2009 Aug;27(4):557-63. Epub 2009 Feb 15.
  14. Upregulation of heme oxygenase-1 expression in gingiva after cyclosporin A treatment. Chiu HC, Lan GL, Chiang CY, Chin YT, Tu HP, Ming-Jen Fu M, Shin N, Fu E. J Periodontol. 2008 Nov; 79(11):2200-6.
  15. Mature solid teratoma of the fallopian tube associated with uterine leiomyomas. Chao TJ, Chao J, Kuan LJ, Li YT, Kuo TC, Chang YC, Nieh S*. J Chin Med Assoc. 2008 Aug;71(8):425-7. *Corresponding author
  16. Aggressive angiomyxoma of supraclavicular fossa: a case report. Pai CY, Nieh S*, Lee JC, Lo CP, Lee HS. Head Neck. 2008 Jun;30(6):821-4. *Corresponding author
  17. EMMPRIN and fascin overexpression associated with clinicopathologic parameters of pancreatobiliary adenocarcinoma in Chinese people.Tsai WC, Chao YC, Sheu LF, Lin YF, Nieh S, Chen A, Yu CP, Jin JS. APMIS. 2007 Aug;115(8):929-38.
  18. Overexpression of fascin-1 in advanced colorectal adenocarcinoma: tissue microarray analysis of immunostaining scores with clinicopathological parameters. Tsai WC, Chao YC, Sheu LF, Chang JL, Nieh S, Jin JS. Dis Markers. 2007;23(3):153-60.
  19. Association of EMMPRIN and fascin expression in renal cell carcinoma: correlation with clinicopathological parameters. Tsai WC, Sheu LF, Nieh S, Yu CP, Sun GH, Lin YF, Chen A, Jin JS. World J Urol. 2007 Mar;25(1):73-80. Epub 2006 Sep 23.
  20. Upregulation of the expression of epidermal growth factor and its receptor in gingiva upon cyclosporin A treatment. Chin YT, Chen YT, Tu HP, Shen EC, Chiang CY, Gau CH, Nieh S, Fu E. J Periodontol. 2006 Apr; 77(4):647-56.
  21. Pineal region teratoma with high serum and CSF alpha-fetoprotein levels. Cheng CM, Chiang YH, Nieh S. J Clin Neurosci. 2006 Feb; 13(2):257-9.
  22. Microvascular transplantation and replantation of the dog submandibular gland. Su WF, Jen YM, Chen SG, Nieh S, Wang CH. Eur Arch Otorhinolaryngol. 2006 May; 263(5):490-4. Epub 2005 Dec 15.
  23. Effect of cyclosporin A on the expression of inducible nitric oxide synthase in the gingiva of rats. Gau CH, Chou TC, Chiu HC, Shen EC, Nieh S, Chiang CY, Fu E. J Periodontol. 2005 Dec; 76(12):2260-6.
  24. Which test is a better strategy to determine the outcome of atypical glandular cell-categorized Pap smears? Immunocytochemical p16INK4A expression or human papillomavirus test--a retrospective cohort study. Chen SF, Yang SF, Chu TY, Lai HC, Lin YW, Bai CY, Nieh S*. Gynecol Oncol. 2005 Dec;99(3):578-84. Epub 2005 Sep 1*Corresponding author
  25. Is p16(INK4A) expression more useful than human papillomavirus test to determine the outcome of atypical squamous cells of undetermined significance-categorized Pap smear? A comparative analysis using abnormal cervical smears with follow-up biopsies. Nieh S*, Chen SF, Chu TY, Lai HC, Lin YS, Fu E, Gau CH. Gynecol Oncol. 2005 Apr;97(1):35-40. *Corresponding author
  26. Detection of the human telomerase RNA component by in situ hybridization in cells from body fluids. Nieh S*, Chen SF, Fu E, Jan CI, Lee WH. Acta Cytol. 2005 Jan-Feb;49(1):31-7. *Corresponding author
  27. Matrix metalloproteinase 1 gene polymorphism as a prognostic predictor of invasive cervical cancer. Lai HC, Chu CM, Lin YW, Chang CC, Nieh S, Yu MH, Chu TY. Gynecol Oncol. 2005 Feb;96(2):314-9.
  28. Genetic polymorphism of the interferon-gamma gene in cervical carcinogenesis. Lai HC, Chang CC, Lin YW, Chen SF, Yu MH, Nieh S, Chu TW, Chu TY. Int J Cancer. 2005 Feb 20;113(5):712-8.
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